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KMID : 0368819920310050895
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Journal of the Korean Neuropsychiatr Association
1992 Volume.31 No. 5 p.895 ~ p.908
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Effect of P-Chlorophenylalanine and Naloxone on Forced Swimming Induced Analgesia in Mice
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Abstract
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In order to test a hypothesis that the hypoalgesia induced by forced swimming in mice is mediated by central opioid neurons and serotonergic neurons, pain sensitivity was measured by means of tail flick test before and after forced swimming and
the
effect of naloxone. Pchlorophenylalanine(PCTA) and 5-hydroxytryptophan(5HTP) on the change of pain sensitivity was observed to obtain the following results.
1) Pain sensitivity was significantly reduced by forced swimming.
2) Hypoalgesia induced by forced swimming was blocked by naloxone pre treatment(2mg/kg).
3) Naloxone pretreatment did not change the pain sensitivity before forced swimming.
4) PCPA pretreatment(300mg/kg once daily for 3days) blocked the hypoalgesic effect induced by forced forced swimming.
5) PCPA pretreatment did not change the pain sensitivity before forced swimming.
6) 5HTP reversed the effect of PCPA.
7) Large dose100-200(mg/kg) of 5HTP not only reversed the effect of PCPA, but also reinforced hypoalgesic effect induced by forced swimming.
8) 5HTP pretreatment did not alter the pain sensitivity before forced swimming in PCPA pretreated and control group.
From these results it is suggested that the hypalgesia induced by forced swimming in mice is mediated by activation of endogenous opioid system that requires coaction of 5HT system.
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